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This selects which barometer will be the primary if multiple barometers are found

This selects the bus number for looking for an I2C barometer

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This sets the specific gravity of the fluid when flying an underwater ROV.

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This sets the range around the average value that new samples must be within to be accepted. This can help reduce the impact of noise on sensors that are on long I2C cables. The value is a percentage from the average value. A value of zero disables this filter.

GPS type

GPS type of 2nd GPS

Navigation filter engine setting

Automatic switchover to GPS reporting best lock

Sets the minimum type of differential GPS corrections required before allowing to switch into DGPS mode.

This sets the SBAS (satellite based augmentation system) mode if available on this GPS. If set to 2 then the SBAS mode is not changed in the GPS. Otherwise the GPS will be reconfigured to enable/disable SBAS. Disabling SBAS may be worthwhile in some parts of the world where an SBAS signal is available but the baseline is too long to be useful.

This sets the minimum elevation of satellites above the horizon for them to be used for navigation. Setting this to -100 leaves the minimum elevation set to the GPS modules default.

The GGS can send raw serial packets to inject data to multiple GPSes.

Masked with the SBP msg_type field to determine whether SBR1/SBR2 data is logged

Handles logging raw data; on uBlox chips that support raw data this will log RXM messages into dataflash log; on Septentrio this will log on the equipment’s SD card and when set to 2, the autopilot will try to stop logging after disarming and restart after arming

Bitmask for what GNSS system to use on the first GPS (all unchecked or zero to leave GPS as configured)

Determines whether the configuration for this GPS should be written to non-volatile memory on the GPS. Currently working for UBlox 6 series and above.

Bitmask for what GNSS system to use on the second GPS (all unchecked or zero to leave GPS as configured)

Controls if the autopilot should automatically configure the GPS based on the parameters and default settings

Controls how often the GPS should provide a position update. Lowering below 5Hz is not allowed

X position of the first GPS antenna in body frame. Positive X is forward of the origin. Use antenna phase centroid location if provided by the manufacturer.

Where information is clear, you should check that:

You should also check whether images have been edited or manipulated to emphasize the story they tell. This may be appropriate but only if authors report on how the image has been edited (e.g. by highlighting certain parts of an image). Where you feel that an image has been edited or manipulated without explanation, you should highlight this in a confidential comment to the editor in your report.

6. List of References

You will need to check referencing for accuracy, adequacy and balance.

Accuracy

Where a cited article is central to the author's argument, you should check the accuracy and format of the reference - and bear in mind different subject areas may use citations differently. Otherwise, it's the editor’s role to exhaustively check the reference section for accuracy and format.

Adequacy

You should consider if the referencing is adequate:

Balance

Check for a well-balanced list of references that is:

You should be able to evaluate whether the article meets the criteria for balanced referencing without looking up every reference.

7. Plagiarism

By now you will have a deep understanding of the paper's content - and you may have some concerns about plagiarism.

Identified Concern

If you find - or already knew of - a very similar paper, this may be because the author overlooked it in their own literature search. Or it may be because it is very recent or published in a journal slightly outside their usual field.

You may feel you can advise the author how to emphasize the novel aspects of their own study, so as to better differentiate it from similar research. If so, you may ask the author to discuss their aims and results, or modify their conclusions, in light of the similar article. Of course, the research similarities may be so great that they render the work unoriginal and you have no choice but to recommend rejection.

"It's very helpful when a reviewer can point out recent similar publications on the same topic by other groups, or that the authors have already published some data elsewhere ." (Editor feedback)

Suspected Concern

If you suspect plagiarism, including self-plagiarism, but cannot recall or locate exactly what is being plagiarized, notify the editor of your suspicion and ask for guidance.

Most editors have access to software that can check for plagiarism.

Editors are not out to police every paper, but when plagiarism is discovered during peer review it can be properly addressed ahead of publication. If plagiarism is discovered only after publication, the consequences are worse for both authors and readers, because a retraction may be necessary.

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WATCH 2 escaped prisoners are on the run in Illinois
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Three inmates, including one charged with murder, busted through the wall of an Illinois jail on Saturday morning and led authorities on a manhunt.

Justin Bray, Zachery Shock and Johnny Tipton allegedly used a pipe to break a hole in the concrete wall of White County Jail in Carmi, Illinois. White County sheriffs were notified of the three missing inmates at 5:30 a.m.

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a metal panel placed over the hole in the wall at the jail.

The White County Sheriff's Office reported Bray was captured Saturday night. Bray is charged with unlawful use of a weapon, aggravated fleeing and resisting or obstructing a peace officer.

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Research Articles
Malin E. Winerdal , David Krantz , Ciputra A. Hartana , Ali A. Zirakzadeh , Ludvig Linton , Emma A. Bergman , Robert Rosenblatt , Janos Vasko , Farhood Alamdari , Johan Hansson , Benny Holmström , Markus Johansson , Max Winerdal , Per Marits , Amir Sherif and Ola Winqvist
Malin E. Winerdal
Department of Medicine, Unit of Allergy and Immunology, Karolinska Institutet, Stockholm, Sweden.
David Krantz
Department of Medicine, Unit of Allergy and Immunology, Karolinska Institutet, Stockholm, Sweden.
Ciputra A. Hartana
Department of Medicine, Unit of Allergy and Immunology, Karolinska Institutet, Stockholm, Sweden.
Ali A. Zirakzadeh
Department of Medicine, Unit of Allergy and Immunology, Karolinska Institutet, Stockholm, Sweden.
Ludvig Linton
Department of Medicine, Unit of Allergy and Immunology, Karolinska Institutet, Stockholm, Sweden.
Emma A. Bergman
Department of Medicine, Unit of Allergy and Immunology, Karolinska Institutet, Stockholm, Sweden.
Robert Rosenblatt
Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden. Department of Urology, Stockholm South General Hospital, Karolinska Institutet, Stockholm, Sweden.
Janos Vasko
Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden.
Farhood Alamdari
Department of Urology, Västmanland Hospital, Västerås, Sweden.
Johan Hansson
Centre for Research and Development, Faculty of Medicine, Uppsala University, County Council of Gävleborg, Uppsala, Sweden.
Benny Holmström
Department of Urology, Uppsala University Hospital, Uppsala, Sweden.
Markus Johansson
Department of Urology, Sundsvall Hospital, Sundsvall, Sweden.
Max Winerdal
Department of Medicine, Unit of Allergy and Immunology, Karolinska Institutet, Stockholm, Sweden.
Per Marits
Department of Medicine, Unit of Allergy and Immunology, Karolinska Institutet, Stockholm, Sweden.
Amir Sherif
Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.
Ola Winqvist
Department of Medicine, Unit of Allergy and Immunology, Karolinska Institutet, Stockholm, Sweden.
10.1158/2326-6066.CIR-17-0466 Published May 2018

Abstract

Regulatory T cells (Treg) have long been considered one-sided suppressors of antitumor immune responses and hence associated with poor patient outcome in cancer. However, evidence is mounting of a paradoxical positive prognostic effect of Tregs on certain malignancies, including urinary bladder cancer (UBC). This discrepancy has partly been attributed to the shear misidentification of Tregs, but also to the inflammatory profile of the tumor. Our aim was to determine whether tumor-infiltrating Forkhead box P3 (FOXP3) cells confer a stable Treg phenotype and to investigate putative beneficial Treg functions, focusing on tumor-promoting inflammatory pathways in UBC. Patients ( = 52) with suspected UBC were prospectively included. We show, by using a broad range of analytical approaches, that tumor-infiltrating CD4FOXP3 T cells in UBC phenotypically, functionally, and epigenetically represent a true Treg population. At the invasive front of UBC tumors, we found an inverse relationship between Treg frequency and expression of matrix metalloproteinase 2 (MMP2), a key proinvasive factor induced by tumor-promoting inflammation. Correspondingly, a significant, dose-dependent Treg-mediated downregulation of MMP2 protein and mRNA expression was observed in both macrophages and UBC cells. Also, we found that Treg frequency specifically at the invasive front positively correlated with survival. Thus, we identify Treg-mediated suppression of MMP2 in the tumor microenvironment as a mechanism explaining the paradoxical positive prognostic impact of tumor-infiltrating Tregs in UBC. .

Footnotes

Note: Supplementary data for this article are available at Cancer Immunology Research Online (http://cancerimmunolres.aacrjournals.org/).

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